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Astrocytes are mainly involved in the synthesis of TGF-β1 in postmortem HD brains. Representative microphotographs of double fluorescent staining for TGF-β1 and GFAP in post-mortem striatal tissues of control subjects and HD patients, showing co-localization between GFAP and TGF-β1 immunoreactive cells at different pathological grades (from II to IV).
