Table 3.
Sizes of protein interaction networks in human, yeast, and E. coli.
| Human | Yeast | E. coli | Total | |
|---|---|---|---|---|
| Nodes | 9917 | 5528 | 2068 | 17513 |
| Non-redundant interactions | 41115 | 39045 | 7197 | 87357 |
| Raw interactions | 77742 | 59336 | 13068 | 150146 |
| Yeast two hybrid (MI:0018) | 13876 | 11055 | 54 | 24985 |
| Anti-tag coimmunoprecipitation (MI:0007) | 1311 | 10049 | 0 | 11360 |
| Pull down (MI:0096) | 6651 | 4024 | 78 | 10753 |
| Experimental interaction detection (MI:0045) | 8243 | 23 | 6 | 8272 |
| Enzymatic study (MI:0415) | 1002 | 2 | 4 | 6491 |
| Inferred by author (MI:0363) | 0 | 388 | 5898 | 6286 |
| Anti-bait coimmunoprecipitation (MI:0006) | 5984 | 22 | 2 | 6008 |
| Tandem-affinity purification (MI:0676) | 317 | 3631 | 1112 | 5060 |
| Others | 40358 | 30142 | 5914 | 76414 |
Non-redundant interactions: each unique combination of interactors A and B is counted as a single interaction, regardless of directionality, experimental system, and data source. Raw interactions: Each unique combination of interactors A and B, experimental system and data source is counted as a single interactiona. Each interaction detection method is annotated with its Ontology Term (e.g. MI:0018).