Figure 2. Retinal degeneration in the Ins2^Akita mouse.

(A) SD-OCT image from 9-month old control retina. Retinal thickness was measured at 300, 600 and 900 µm eccentricities in dorso-ventral and nasal-temporal retinal regions, from NFL-OS (total retinal thickness), NFL-INL (inner retinal thickness) and OPL-OS (outer retinal thickness). Isodensity maps (B) and quantitative analysis (C) of total retinal thickness from control and Ins2^Akita mice at different ages. (D) The cumulative reduction of outer, inner and total retinal thickness in different ages of control and Ins2^Akita mice. Fundus (E, H) and OCT images (F-G, I-J) taken from 9-month old control (A-C) and Ins2^Akita mice (D-F). (B-D) n = 6 mice per strain/age, *P<0.05, ** P<0.01, *** P<0.001 compared to control mice of the same age. Student's t-test. RPE, retinal pigment epithelium; IS/OS, photoreceptor inner/outer segments; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL/NFL, ganglion/nerve fibre layer.