Table 2.

Data items collected for the study and source

Data item	Source
Data collected specifically for this study
Name, date of birth, address, postcode	Baseline questionnaire, RADIS2
NHS number
Employment status	Baseline questionnaire
Smoking and alcohol use
Obstetric history
Weight	RADIS2 or paper proforma
Height
BMI
Presence or absence of the following markers:
Cardiac Echogenic Foci, Choroid Plexus Cyst, Echogenic Bowel, Mild Ventriculomegaly, Nuchal Thickening, Short Femur, Pelvicalyceal Dilatation
Routinely collected data
Pregnancy outcome, live birth, stillbirth, gestation at birth, birth weight, neonatal death, infant death	NCCHD and AWPS
Presence of any structural abnormality, congenital malformation or cystic fibrosis	CARIS
Cytogenetic information	Cardiff and Vale Cytogenetic laboratory, CARIS
Down’s syndrome risk	NHS Biochemistry laboratory