Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 May 6;13:104. doi: 10.1186/1476-4598-13-104

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Mannoor et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Effect of snoRA42 suppression on tumor formation of CD133+ cells isolated from NSCLC cell lines and expressions of stem cell-associated genes. (A) After six weeks, 5 X 10⁵ Calu-1-derived CD133+ cells transfected with scrambled siRNA were able to generate tumor xenografts (red arrow) in all six mice. However, 5 X 105 Calu-1-derived CD133+ cells transfected with snoRA42-siRNA could not produce tumor in any mice. (B) Knockdown of snoRA42 using snoRA42-siRNA in H-1944- and Calu-1-derived CD133+ cells resulted in a significant reduction in transcriptional activity of stem-associated genes determined by qRT-PCR.