Table 5. Association between BRCA1 promoter region genetic variants and BRCA1 promoter methylation detected in group 1 women.
| rs number | Genotype | Methylated (n=16) |
Not methylated (n=36) |
Allelic test P-value |
OR (95% CI) |
|---|---|---|---|---|---|
| rs8176072 | TT | 16 | 32 | 0.31 | 0 |
| AT | 0 | 4 | |||
| AA | 0 | 0 | |||
| rs8176073 | AA | 16 | 35 | 1 | 0 |
| AG | 0 | 1 | |||
| GG | 0 | 0 | |||
| rs11655505 | CC | 4 | 22 | 0.035 | 2.7 (1.11–2.67) |
| CT | 10 | 12 | |||
| TT | 2 | 2 | |||
| rs799906 | AA | 4 | 23 | 0.017 | 3.11 (1.25 to 7.74) |
| AG | 10 | 10 | |||
| GG | 2 | 2 |