Table 3.

Association between variable duration of PPI exposure and TB infection/activation

Exposure	Case (%) n = 6541	Control (%) n = 65410	Crude OR	Adjusted OR †
3 months
Non user	6368(97.36)	64687(98.89)	1	1
User	173(2.64)	723(1.11)	2.43(2.06-2.88)	1.63(1.62-1.63)
6 months
Non user	6306(96.41)	64276(98.27)	1	1
User	235(3.59)	1134(1.73)	2.11(1.83-2.44)	1.29(1.29-1.30)
12 months
Non user	6221(95.11)	63575(97.19)	1	1
User	320(4.89)	1835(2.81)	1.78(1.58-2.01)	0.99(0.99-1.01)
24 months
Non user	6103(93.30)	62519(95.58)	1	1
User	438(6.70)	2891(4.42)	1.55(1.40-1.72)	0.90(0.89-0.90)

Abbreviations: OR, odds ratio. †Adjusted for socioeconomic status, congestive heart failure, coronary heart disease, chronic pulmonary disease, diabetes mellitus, end stage renal disease, liver cirrhosis, alcohol abuse, peptic ulcer disease, reflux esophagitis, gastrectomy, HIV, connective tissue disease, malignant neoplasm, organ transplantation.