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. 2014 May 15;63(6):1920–1932. doi: 10.2337/db13-1604

Figure 2.

Figure 2

Adipose tissue expansion in Mfap2−/− mice is associated with metabolic dysfunction. A: GTT and ITT results in 5- to 6-month-old mice, following 12-h overnight fast and 1 g/kg dextrose injection or 6-h fast and 0.75 units/kg insulin injection (n = 7–10). B: High-fat feeding exacerbates the metabolic dysfunction associated with MAGP1 deficiency. Whole-body fat content in response to control chow and HFD (60% fat) was determined by EchoMRI (mean ± SEM; n = 8–10). C: 6-h fast blood glucose levels in WT and Mfap2−/− (−/−) mice fed chow or HFD for 12 weeks (mean ± SEM; n = 8–10). D: Serum insulin concentration in response to 1 g/kg dextrose injection; WT and Mfap2−/− mice were fed chow or HFD for 12 weeks (mean ± SEM; n = 7–10). E: ITT results following 6-h fast and 0.75 units/kg insulin injection in WT and Mfap2−/− mice consuming chow or HFD for 13 weeks (n = 8–10 per group). F: Ectopic lipid accumulation is enhanced in MAGP1-deficient tissue. Biopsy EchoMRI and histology (hematoxylin-eosin; scale bar 400 μm) was performed on liver from WT and Mfap2−/− mice that consumed HFD for 14 weeks (mean ± SEM; n = 5–6). Student t test was used for single comparisons, *P < 0.05.