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. 2014 May 14;7:39. doi: 10.3389/fnmol.2014.00039

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Copyright © 2014 Uren and Turnley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trk receptor signaling pathways. Upon neurotrophin binding, the activated Trk receptors engage various intracellular signaling pathways such as those mediated by extracellular signal-regulated kinases (ERKs), phosphatidylinositol 3-kinase (PI3K) and phospholipase Cγ (PLC-γ) to promote cellular differentiation, growth, survival, synaptic plasticity and changes to cell motility (adapted from Huang and Reichardt, 2003). Critical tyrosine (Y) residues of the human TrkA intracellular domain are shown. Direct, indirect and inhibitory pathways are denoted by solid arrows, dashed arrows and blunt arrows respectively.