Figure 1.

Contextual Serial Discrimination: at the acquisition phase, mice performed two consecutive spatial discriminations varying by the color and texture of the floor, i.e., D1: Discrimination 1 and D2: Discrimination 2. For each discrimination, only one hole out of the 4 holes of the apparatus was baited (hashed circles). A 24-h delay was interpolated between the acquisition and test phases, during which mice were returned in the animal room. Fifteen minute (post-stress delay) prior to behavioral testing, mice received an electric footshock in a chamber placed in a room (room C) different from the one in which the behavioral experiments was conducted (room A). Subsequently, mice were submitted to the test phase in which they were replaced either on the floor of the first or the second discrimination without any food pellet in the apparatus. Compound injections occurred 30 min (Experiment 1) or 15 min (Experiment 3) before behavioral testing.