Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 May 15;8:166. doi: 10.3389/fnbeh.2014.00166

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Dominguez, Faucher, Henkous, Krazem, Piérard and Béracochéa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects of lidocaine injections into the dHPC and mPFC on memory patterns in the CSD task in non-stress and stress conditions. (A) dHPC. Discrimination 1, D1 Left: Percentage of correct responses in vehicle and lidocaine-injected mice in non-stress and stress conditions. Lidocaine was injected 15 min before stress delivery (which occurred 15 min before test) thus 30 min before behavioral testing. Stress and lidocaine induced a significant decrease of the % of correct responses (^***p < 0.001 vs. Vehicle non-stress). (A) Discrimination 2, D2 right: Percentage of correct responses in vehicle and lidocaine-injected mice in non-stress and stress conditions. Stress and lidocaine induced a significant increase of the % of correct responses (^***p < 0.001 vs. Vehicle non-stress); (B) mPFC: Discrimination 1, D1: Left: Percentage of correct responses in vehicle and lidocaine-injected mice in non-stress and stress conditions. Stress significantly decreased the % of correct responses (^***p < 0.001 vs. Vehicle non-stress); in contrast, lidocaine had no effect in non-stress condition as compared the Vehicle non-stress group (NS) and lidocaine did not blocked the deleterious effect of stress on performance (Lidocaine+stress vs. Lidocaine non-stress; ^***p < 0.001). Discrimination 2, D2: right: Percentage of correct responses in vehicle and lidocaine-injected mice in non-stress and stress conditions. Stress induced a significant increase of the % of correct responses (^***p < 0.001 vs. Vehicle non-stress). Lidocaine blocked the stress-induced increase of the % of correct responses (^***p < 0.001 vs. Vehicle+stress).