Table 1.
Pim1 as a proviral integration site.
| Virus | Mouse strain | Locus of insertion (frequency %) | Tumor type |
|---|---|---|---|
| M-MuLV | BALB/c, C57BL | 3′Region of pim1 (50%) | Early T-cell lymphoma (5) |
| M-MuLV | BALB/c, C57BL | 3′Region of pim1 (50%); 3′region of c-myc (45%) | Early T-cell lymphoma (6) |
| M-MuLV | BALB/c | 3′and 5′Regions of pim1 (50% early lymphomas, 7% late lymphomas) | Early and late T-cell lymphoma (8) |
| M-MuLV | BALB/c, C57BL | Oligoclonal and monoclonal in c-myc and pim1 | Early T-cell lymphoma (7) |
| M-MuLV | AKXD | 3′Region of pim1; 3′region of c-myc | T- and B-cell lymphomas (9) |
| Ecotropic virus | HRS/J, C58/J | 3′Region of pim1 (11%) | T-cell lymphoma (12) |
| Mo+, Mo + PYwt, Mo + PyF441 M-MuLVs | NIH Swiss | Mo + pim1 (33%), Mo + PYwt pim1 (13.3%), Mo+ PyF441 no insertion | Lymphoblastic lymphoma (18) |
| M-MuLV | BALB/c, C57BL, B6 nude (nu/nu) | No insertion at the pim1 locus | B-cell lymphomas (19) |
| Transplanted lymphomas induced by M-MuLV | BALB/c, C57BL10 | Retain integration in c-myc, pim-1 enrichment of pim-2 insertion from 10% to over 50% | T-cell lymphoma (14) |
| M-MuLV | BALB/c, C57BL10 | pim2 and pim1 (21%); 10% of cells affected | T-cell lymphoma (14) |
| Friend helper leukemia virus (F-MuLV) | ICFW | p53 (35%), p53 and pim-1 (24%), p53 and c-myc (6%), c-myc (12%) | Erythroleukemia (15) |
| M-MuLV and bcr-abl/M | BALB/c | M-MuLV: pim1 (33%); bcr-abl/M: pim1 (14%) | Thymoma (16) |
| Graffi murine leukemia viruses | Balb/c and NFS | pim1 (3%) | Myeloblastic leukemia (17) |