Table 3.

Mouse models with deletions of the Pim proteins.

Mouse model	Phenotype	Reference
Pim1−/−	Erythrocyte microcytosis. Impaired response to IL7 and SF. HSCs showed impaired long-term hematopoietic repopulating capacity in secondary and competitive transplantations. Fail to consolidate enduring long-term potentiation	(31, 37, 39, 40)
Pim2−/−	HSCs mice behaved normally in a long-term hematopoietic repopulating capacity in secondary and competitive transplantations	(31)
Pim3−/−	HSCs mice behaved normally in a long-term hematopoietic repopulating capacity in secondary and competitive transplantations	(31)
Pim1−/−; Pim2−/−; Pim3−/−(TKO)	TKO mice exhibited reduced body size, a severely impaired in vitro response of distinct hematopoietic cell populations to growth factors, thrombocytopenia, and hypochromic erythrocytes. HSCs showed impaired long-term hematopoietic repopulating capacity in secondary and competitive transplantations	(43, 45)
Pim2−/−; Pim3−/−(DKO) TKO	Absence of Pim2 and Pim3 greatly reduced the sarcoma growth induced by 3MC, to an extent similar that observed in the absence of all three isoforms. The lack of Pim2 and Pim3 reduced tumor-induced bone invasion by 70%, which is comparable to the reduction of tumor-induced bone invasion in the absence of all three isoforms	(44)