Table 1.

Distance constraints for the various active state models. Constraints that were used to derive each model are shaded in the respective column

derived for	residues involved	change	R0	R1	R2	R3	R4	R5
RHO	TM1/TM7-H8 (1.60/7.53)	increase
RHO	TM1/TM7-H8 (1.60/7.57)	increase
RHO	TM1/TM7-H8 (1.56-1.60/7.59)	~
MC4R	TM2/TM3 (2.60/3.28)	6.5<>8.5
MC4R	TM2/TM3 (2.64/3.25)	6.5<>8.5
RHO	TM3/TM5 (3.51/5.57)	increase
RHO	TM3/TM5 (3.51/5.60)	decrease
RHO	TM3/TM5 (3.53/5.57)	increase
RHO	TM3/TM5 (3.53/6.30)	decrease
RHO	TM3/TM6 (3.49-52/6.30-35)	increase
NK1, β2ar	TM3/TM7 (3.32/7.39)	6.5<>8.5
RHO	TM5/TM6 (5.33-5.39/6.59)	decrease
Mm3 mACHR	TM5/TM6 (5.62/6.34-6.36)	decrease
β2ar	TM5/TM6 (5.63/6.27)	decrease
Ste2p	TM5/TM6 (5.30/6.61)	<10
RHO	various	various