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Loss of electrocorticogram (ECG) signature in Alzheimer's disease (AD) mice. Insulin-like growth factor I (IGF-I) induces significant increases in α, β and θ ECG frequency bands and a decrease in δ-wave in control animals. In contrast, both double- and single-mutant AD mice showed no changes. Average changes in ECG bands from 20 to 60 min after IGF-I injection were compared with average baseline levels (paired t-test: **P<0.01, ***P<0.001 vs baseline).
