Table 2. Influence of Genetic Polymorphisms on Levels of Vitamin D–Binding Protein and Total 25-Hydroxyvitamin D*.
| SNP | Reference Allele | Variant Allele | Variant Allele Frequency | Change in Vitamin D–Binding Protein Level per Variant Allele Copy (95% CI) | P Value | Change in Total 25-Hydroxyvitamin D Level per Variant Allele Copy (95% CI) | P Value |
|---|---|---|---|---|---|---|---|
| μg/ml | ng/ml | ||||||
|
| |||||||
| Blacks | |||||||
|
| |||||||
| rs7041 | G | T | 0.83 | −189.4 (−195.7 to −183.1) | <0.001 | −2.0 (−2.9 to −1.1) | <0.001 |
|
| |||||||
| rs4588 | C | A | 0.10 | 57.0 (49.2 to 64.7) | <0.001 | −0.5 (−1.7 to 0.6) | 0.33 |
|
| |||||||
| Whites | |||||||
|
| |||||||
| rs7041 | G | T | 0.42 | −189.1 (−201.0 to −177.3) | <0.001 | 0.2 (−1.3 to 1.7) | 0.77 |
|
| |||||||
| rs4588 | C | A | 0.28 | 48.9 (36.0 to 61.8) | <0.001 | −2.5 (−4.1 to −0.9) | 0.003 |
*
Data on 1126 blacks and 855 whites were included in the analysis. CI denotes confidence interval, and SNP single-nucleotide polymorphism. P values of less than 0.025 were considered to indicate statistical significance (adjusted for two SNPs).