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. Author manuscript; available in PMC: 2014 May 22.

Published in final edited form as: Otol Neurotol. 2010 Sep;31(7):1135–1143. doi: 10.1097/MAO.0b013e3181eb328a

Change in pure-tone thresholds after treatment using erlotinib 150 mg daily. The vertical line indicates the start of treatment (day 0). Patients who did not undergo audiologic evaluation (n=1) and those with surgical resection of both auditory nerves (n=1) were excluded from analysis. (a) Minor response (defined as increase in pure tone average of 10 dBHL from baseline in the setting of stable word recognition) was noted in two patients and stable hearing in three patients. (b) Progressive hearing decline was documented in 3 patients.

Change in pure-tone thresholds after treatment using erlotinib 150 mg daily. The vertical line indicates the start of treatment (day 0). Patients who did not undergo audiologic evaluation (n=1) and those with surgical resection of both auditory nerves (n=1) were excluded from analysis. (a) Minor response (defined as increase in pure tone average of 10 dBHL from baseline in the setting of stable word recognition) was noted in two patients and stable hearing in three patients. (b) Progressive hearing decline was documented in 3 patients.