Table 1.

Possible effects of new treatments on physiological changes seen in COPD. Review of the literature [47–54] suggests that p38 MAPK inhibitors, TNFα inhibitors, and IKK2 inhibitors may inhibit many of the physiological changes seen in COPD and could serve as useful therapies for this disease.

COPD Manifestations	P38 MAPK inhibitors	TNFα inhibitors	IKK2 Inhibitors
Airflow Limitation	+[47]	+[48]	+[49]
Mucus Hypersecretion	+[50]	unknown	unknown
Alveolar Destruction	unknown	+[51]	+[49]
Pulmonary Vasoconstriction	+[52]	unknown	unknown
Skeletal Muscle Weakness	+[53]	+[54]	+[54]