Table I.
Gene (mRNA) expression study
|
MicroRNA expression study
|
|||
---|---|---|---|---|
Characteristics | High Vitamin D (≥31.7 ng/ml)* |
Low Vitamin D (<25.5 ng/ml) |
High Vitamin D (≥31.7 ng/ml) |
Low Vitamin D (<25.5 ng/ml) |
Number (N) | 11 | 10 | 6 | 7 |
Age, years** | 34.18 (3.9) | 33.2 (5.5) | 34.33 (3.1) | 33.43 (2.4) |
Gestational Age, weeks** | 15.91 (2.2) | 16.3 (2.5) | 15.14 (1.9) | 16.84 (2.1) |
Pre-pregnancy BMI (kg/m2)** | 21.58 (3.1) | 23.39 (2.8) | 22.87 (3.7) | 26.40 (5.6) |
Overweight (≥24kg/m2) | 1 (10%) | 3 (30%) | 2 (29%) | 1 (14%) |
Non-Hispanic Whites | 11 (100%) | 10 (100%) | 6 (100%) | 7 (100%) |
Married | 11 (100%) | 9 (90%) | 6 (100%) | 7 (100%) |
Nulliparous | 5 (45%) | 4 (40%) | 4 (66.7%) | 3 (42.9%) |
Gravidity** | 2.64 (1.62) | 2.10 (1.60) | 2.17 (2.4) | 2.00 (0.6) |
Season of blood draw | ||||
Spring/Summer | 5 (46.5) | 5 (50%) | 2 (33.3%) | 3 (42.9%) |
Fall/Winter | 6 (64.5) | 5 (50%) | 4 (66.7%) | 4 (57.1%) |
Plasma 25-hydroxyvitamin D (25-[OH] D) concentrations, ng/ml** | 38.84 (7.0) | 22.09 (2.6) | 39.22 (6.1) | 22.84 (2.0) |
mean (standard deviation), otherwise number (%)
Assessed by measuring maternal early pregnancy plasma 25-hydroxyvitamin D (25-[OH] D) concentrations
Abbreviations: GA=gestational age at blood draw, BMI=body mass index
The only statistically significant difference (p-value < 0.05) between the two groups in each experiment is the difference between vitamin D levels.