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. Author manuscript; available in PMC: 2014 May 22.
Published in final edited form as: Cell. 2013 May 9;153(4):759–772. doi: 10.1016/j.cell.2013.04.030

Figure 2. DNA Methylation Dynamics at TSS Regions.

Figure 2

(A) Four distinctive cohorts in regard to DNAme at TSS regions. k-means clustering (k = 4) of DNAme (mean fraction CG methylation, TSS ± 250 bp). (B–F) Class average DNAme plots were generated on TSS (±2 kb) for gene classes as defined by GO terms or those containing zCGIs. (G) Obs/exp frequency was calculated for each TSS cluster in (A). (H–L) Snapshots visualized on Integrated Genome Browser (IGB) for dnmt6, dnmt3, hoxd cluster, dazl, gata1a, and sox10 (DNAme scale: 0 to 1, mean base fraction CG methylation).

See also Figure S6 and Tables S2, S4, S5 and S7.