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. Author manuscript; available in PMC: 2014 May 22.
Published in final edited form as: Toxicol Appl Pharmacol. 2010 Apr 24;246(0):58–65. doi: 10.1016/j.taap.2010.04.006

Table 1.

Electron transport chain complexes and regulated genes

graphic file with name nihms-209305-t0005.jpg
Complex I
NADH
Dehydrogenase		 Complex II
Succinate
Dehydrogenase		 Complex III
Cytochrome c
Reductase		 Complex IV
Cytochrome c
Oxidase		 Complex V
F0F1 ATPase		 UCP
Uncoupling
Protein		 Chaperone
Mitochondrial
genome encoded
subunits		 7 0 1 3 2 0 0
Nuclear genome
encoded subunits		 40 4 10 15 19 5 3
Number of
differentially
regulated genesa 		26 - 8 8 9 2 1
Most temporally
regulatedb 		Ndufb6 - Uqcrc1 Cox4i1 Atpaf1 Ucp2 Sco1
(Fold changed)c ▼ 9.1 ▲ 3.2 ▲ 4.0 ▲ 5.3 ▲ 3.1 ▼ 1.64
Dose-responsived Ndufa10 - Cyc1 Cox7b Atp5g3 Ucp2 Sco1
Atp5l Ucp5
a

Where |fold change| > 1.5 and P-value < 0.1 in the time course experiment

b

Gene exhibiting maximum temporal fold change across the time course experiment with P-value < 0.1 in the given ETC complex

c

Maximum temporal fold change across the time course experiment with P-value < 0.1

d

Gene exhibiting dose-response to TCDD in the given ETC complex