Table 2.
Time course identified differentially regulated genes elicited by 30μg/kg TCDD using HTP-QRTPCR
| RefSeq Accession |
Entrez Gene ID |
Complex | Gene Name | Gene Symbol |
Fold Changea | Time Pointb |
|---|---|---|---|---|---|---|
| NM_024197 | 67273 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 | Ndufa10 | ▲ 2.3 | 24, 168 |
| NM_027244 | 69875 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11 | Ndufa11 | ▲ 2.4 | 2, 24 |
| NM_025551 | 66414 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 12 | Ndufa12 | ▲ 1.9 | 18, 24 |
| NM_001127346 | 75597 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2 | Ndufa12l | ▲ 1.9 | 168 |
| NM_010886 | 17991 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 | Ndufa2 | ▲ 1.6 | 168 |
| NM_025348 | 66091 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 3 | Ndufa3 | ▲ 2.4 | 2, 12, 24 |
| NM_010886 | 17992 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 | Ndufa4 | ▲ 2.9 | 2, 4. 24 |
| NM_001098789 | 407790 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | Ndufa4l2 | ▲ 2.2 | 168 |
| NM_026614 | 68202 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5 | Ndufa5 | ▼ 1.6 | 18 |
| NM_025987 | 67130 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 6 (B14) | Ndufa6 | ▼ 3.1 | 18 |
| NM_023202 | 66416 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 7 (B14.5a) | Ndufa7 | ▲ 1.8 | 72 |
| NM_026703 | 68375 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 8 | Ndufa8 | ▲ 4.8 | 8, 168 |
| NM_027175 | 69702 | Complex I | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1 | Ndufaf1 | ▲ 2.0 | 2 |
| NM_026684 | 68342 | Complex I | NADH dehydrogenase (ubiquinone) 1 beta subcomplex 10 | Ndufb10 | ▲ 2.2 | 4 |
| NM_019435 | 104310 | Complex I | NADH dehydrogenase (ubiquinone) 1 beta subcomplex 11 | Ndufb11 | ▲ 2.1 | 168 |
| NM_026612 | 68198 | Complex I | NADH dehydrogenase (ubiquinone) 1 beta subcomplex 2 | Ndufb2 | ▲ 2.1 | 168 |
| NM_025597 | 66495 | Complex I | NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 | Ndufb3 | ▲ 2.7 | 24 |
| NM_001033305 | 230075 | Complex I | NADH dehydrogenase (ubiquinone) 1 beta subcomplex 6 | Ndufb6 | ▼ 9.1 | 2, 8, 24 |
| NM_025843 | 66916 | Complex I | NADH dehydrogenase (ubiquinone) 1 beta subcomplex 7 | Ndufb7 | ▲ 4.8 | 4 |
| NM_024220 | 68197 | Complex I | NADH dehydrogenase (ubiquinone) 1 subcomplex unknown 2 | Ndufc2 | ▲ 2.1 | 4 |
| NM_145518 | 227197 | Complex I | NADH dehydrogenase (ubiquinone) Fe-S protein 1 | Ndufs1 | ▲ 2.8 | 4, 168 |
| NM_153064 | 226646 | Complex I | NADH dehydrogenase (ubiquinone) Fe-S protein 2 | Ndufs2 | ▲ 2.1 | 4, 8 |
| M_026688 | 68349 | Complex I | NADH dehydrogenase (ubiquinone) Fe-S protein 3 | Ndufs3 | ▲ 2.5 | 2, 18, 168 |
| NM_144870 | 225887 | Complex I | NADH dehydrogenase (ubiquinone) Fe-S protein 8 | Ndufs8 | ▲ 2.7 | 72 |
| NM_028388 | 72900 | Complex I | NADH dehydrogenase (ubiquinone) flavoprotein 2 | Ndufv2 | ▼ 2.4 | 12, 18 |
| NM_030087 | 78330 | Complex I | NADH dehydrogenase (ubiquinone) flavoprotein 3 | Ndufv3 | ▲ 3.5 | 4, 18 |
| NM_025567 | 66445 | Complex III | Cytochrome c-1 | Cyc1 | ▲ 1.7 | 72 |
| NM_025710 | 66694 | Complex III | Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | Rieske | ▲ 1.7 | 12 |
| NM_197979 | 66152 | Complex III | Ubiquinol-cytochrome c reductase (7.2 kD) subunit | Ucrc | ▼ 1.8 | 18 |
| NM_025650 | 66594 | Complex III | Ubiquinol-cytochrome c reductase (6.4kD) subunit | Uqcr | ▲ 1.9 | 72 |
| XM_484346 | 432822 | Complex III | Ubiquinol-cytochrome c reductase binding protein | Uqcrb | ▼ 1.6 | 18 |
| NM_025407 | 22273 | Complex III | Ubiquinol-cytochrome c reductase core protein 1 | Uqcrc1 | ▲ 3.2 | 168 |
| NM_025899 | 67003 | Complex III | Ubiquinol-cytochrome c reductase core protein 2 | Uqcrc2 | ▲ 2.7 | 4, 24, 72 |
| NM_025352 | 22272 | Complex III | Ubiquinol-cytochrome c reductase, complex III subunit VII | Uqcrq | ▼ ▲1.7 | 4, 18 |
| NM_009941 | 12857 | Complex IV | Cytochrome c oxidase subunit IV isoform 1 | Cox4i1 | ▲4.0 | 72 |
| NM_053091 | 84682 | Complex IV | Cytochrome c oxidase subunit IV isoform 2 | Cox4i2 | ▲ 1.7 | 168 |
| NM_009942 | 12859 | Complex IV | Cytochrome c oxidase, subunit Vb | Cox5b | ▲ 1.6 | 2 |
| NM_009943 | 12862 | Complex IV | Cytochrome c oxidase, subunit Via, polypeptide 2 | Cox6a2 | ▼ 2.3 | 8, 18 |
| NM_025628 | 110323 | Complex IV | Cytochrome c oxidase, subunit Vib polypeptide 1 | Cox6b1 | ▲ 3.1 | 2, 72, 168 |
| NM_053071 | 12864 | Complex IV | Cytochrome c oxidase, subunit Vic | Cox6c | ▲ 2.7 | 4, 168 |
| NM_009945 | 12866 | Complex IV | Cytochrome c oxidase, subunit VIIa 2 | Cox7a2 | ▲ 2.1 | 72 |
| NM_025379 | 66142 | Complex IV | Cytochrome c oxidase, subunit VIIb | Cox7b | ▲ 2.1 | 72 |
| NM_181040 | 230649 | Complex V | ATP synthase mitochondrial F1 complex assembly factor 1 | Atpaf1 | ▲ 5.3 | 2, 24 |
| NM_145427 | 246782 | Complex V | ATP synthase mitochondrial F1 complex assembly factor 2 | Atpaf2 | ▼ 2.3 | 12 |
| NM_016774 | 11947 | Complex V | ATP synthase, H+ transporting, mitochondrial F1 complex, beta subunit | Atp5b | ▼ 2.1 | 8, 168 |
| NM_025313 | 66043 | Complex V | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit | Atp5d | ▲ 2.0 | 2 |
| NM_009725 | 11950 | Complex V | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 | Atp5f1 | ▲ 2.5 | 8, 168 |
| NM_026468 | 67942 | Complex V | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2 | Atp5g2 | ▲ 1.6 | 72 |
| NM_175015 | 228033 | Complex V | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 3 | Atp5g3 | ▲ 2.0 | 72 |
| NM_016755 | 11957 | Complex V | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f | Atp5j | ▼ 1.7 | 8 |
| NM_013795 | 27425 | Complex V | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g | Atp5l | ▼ 1.8 | 18, 168 |
| NM_011671 | 22228 | UCP | Uncoupling protein 2 (mitochondrial, proton carrier) | Ucp2 | ▲ 3.1 | 4 |
| NM_028711 | 74011 | UCP | Uncoupling protein 4 (mitochondrial solute carrier) | Ucp4 | ▲ 2.2 | 168 |
| NM_001040026 | 52892 | Chaperone | SCO cytochrome oxidase deficient homolog 1 (respiratory chain complex IV assembly) | Sco1 | ▲ 1.7 | 4 |
a
Time points with maximum fold change and P-value < 0.1
b
| fold changej > 1.5 and P-value < 0.1