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. Author manuscript; available in PMC: 2014 May 22.
Published in final edited form as: Toxicol Appl Pharmacol. 2010 Apr 24;246(0):58–65. doi: 10.1016/j.taap.2010.04.006

Table 3.

Temporal distribution of differentially regulated genes after 3 μg/kg TCDD exposure

Time point
(hrs)		 Number of
Differentially
Regulated Genes		 Primary Complex Altered Genes Meeting Cut-offs
2 10 Complex I Ndufal 1, Ndufa3, Ndufa4, Ndufafl, Ndufb6, Ndufs3,
Cox5b, Cox6b1, Atpaf1, Atp5d
4 10 Complex I Ndufa4, Ndufb10, Ndufb7, Ndufs1, Ndufs2, Ndufv3,
Uqcrc2, Uqcrq, Cox6c, Ucp2
8 7 Complex I and V Ndufa8, Ndufb6, Ndufs2, Cox6a2, Atp5b, Atp5f1,
Atp5j
12 4 Complex I Ndufa3, Ndufv2, Rieske, Atpaf2
18 12 Complex I Ndufa12, Ndufa5, Ndufa6, Ndufs3, Ndufv2, Ndufv3,
Ucrc, Uqcrb, Uqcrq, Cox6a2, Atp5l, Sco1
24 10 Complex I Ndufa10, Ndufa11, Ndufa12, Ndufa3, Ndufa4, Ndufb3,
Ndufb6, Ndufc2, Uqcrc2, Atpaf1
72 11 Complex IV Ndufa7, Ndufs8, Cyc1, Uqcr, Uqcrc2, Cox4i1,
Cox6b1, Cox7a2, Cox7b, Atp5g2, Atp5g3
168 17 Complex I Ndufa10, Ndufa12l, Ndufa2, Ndufa4l2, Ndufa8,
Ndufb11, Ndufb2, Ndufs1, Ndufs3, Uqcrc1, Cox4i2,
Cox6b1, Cox6c, Atp5b, Atp5f1, Atp5l, Ucp4

Note: genes included meet statistical (P-value < 0.1) and fold change (fold change| > 1.5) cut-offs. Primary complex altered indicates the complex most represented at that time point.