Table 4.
DRE distribution within the genomic sequence of dose-responsive genes
| Gene | ETC Complex | 5-10kb upstream of TSS |
Within 5Kb of TSS |
In Introns |
In Exons |
In 5′ UTR |
In 3′ UTR |
|---|---|---|---|---|---|---|---|
| Ndufa10 | Complex I | 1 | 1 | 6 | 0 | 0 | 0 |
| Cyc1 | Complex III | 3 | 5 | 2 | 0 | 1 | 0 |
| Cox7b | Complex IV | 2 | 6 | 0 | 1 | 0 | 0 |
| Atp5g3 | Complex V | 1 | 1 | 1 | 0 | 0 | 0 |
| Atp5l | Complex V | 5 | 1 | 0 | 0 | 0 | 0 |
| Ucp2 | Uncoupled Protein | 4 | 2 | 3 | 0 | 0 | 0 |
| Ucp5 | Uncoupled Protein | 0 | 2 | 4 | 1 | 0 | 1 |
| Sco1 | Chaperone | 6 | 3 | 8 | 0 | 0 | 0 |
Note: Identified DREs must have a similarity score >0.8 as identified in UCSC mouse build 37