. Author manuscript; available in PMC: 2015 Apr 15.

Published in final edited form as: Bioorg Med Chem. 2014 Mar 6;22(8):2542–2552. doi: 10.1016/j.bmc.2014.02.043

Table 1.

Activity of schweinfurthin indoles in the NCI 60 cell line screen.

cmpd	NSC#	R¹	R²	R³	R⁴	R⁵	Mean GI₅₀ (nM)	GI₅₀Range (log₁₀ units)	n	SF-295 GI₅₀ (nM)
5	750658	H	H	H	H	H	570	3.29	2^a	89
6	750655	CH₃	H	H	H	H	1020	2.02	2^a	230
7	752116	CH₃	H	prenyl	H	H	3160	3.08	2^a	290
8	752816	CH₃	H	H	prenyl	H	390	3.00	2^a	<21^b
18	750656	CH₃	H	H	geranyl	H	1620	3.19	1	110
19	751060	CH₃	H	H	H	CH₃	380	2.41	1	55
20	752115	CH₃	CH₃	H	H	H	1260	2.63	2^a	760
21	752114	CH₃	CH₃	H	H	CH₃	1260	2.61	2^a	170
38	751061	CH₃	H	H	geranyl	CH₃	1070	2.54	1	200
43	754492	CH₃	H	H	prenyl	CH₃	430	2.38	2^a	48
47	752817	H	CH₃	H	H	CH₃	450	3.00	2^a	<12^b
50	754493	H	H	H	prenyl	CH₃	580	3.26	2^a	<23^b
3	740544	Schweinfurthin F					780	2.79	2^a	<36^b
4	744343	Schweinfurthin G					110	3.12	2^a	10

Data represents the average of two independent experiments.

In one experiment the GI₅₀ was below the lowest concentration tested (10 nM).