FIG 4 .

Altered histone modifications play a significant role in both H5N1 and MERS-CoV ISG antagonism. Chromatin immunoprecipitation with antibodies against H3K4me3 (A and C) or H3K27me3 (B and D) followed by qPCR of the 5′UTR of the identified genes 12 h postinfection with H1N1-09 (red), H5N1-VN1203 (blue), SARS-CoV (green), or MERS-CoV (orange). Values represent fold increase binding compared to mock on a log₂ scale. P values based on Student’s t test and are marked as indicated: *, <0.05; **, <0.01; ***, <0.001.