Table 3.
Metabolic features before and after 12 weeks of therapy
| |
Metformin |
Exercise Training |
Metformin and Exercise Training |
||||||
|---|---|---|---|---|---|---|---|---|---|
| PRE | POST | P value | PRE | POST | P value | PRE | POST | P value | |
| Homa |
5.1 ± 3.0 |
3.1 ± 1.3 |
<0.05 |
5.5 ± 3.3 |
3.2 ± 1.1 |
<0.05 |
5.6 ± 2.1 |
3.3 ± 1.2 |
<0.05 |
| BMI (Kg/m2) |
29.7 ± 4.8 |
28.4 ± 4.6 |
<0.05 |
28.3 ± 4.7 |
28.9 ± 5.6 |
ns |
31.8 ± 3.8 |
29.8 ± 3.8 |
<0.01 |
| VO2 (l/min) |
1.5 ± 0.4 |
1.5 ± 0.3 |
<0.01 |
1.4 ± 0.1 |
1.70 ± 0.5 |
<0.05 |
1.7 ± 0.5 |
1.8 ± 0.4 |
<0.05 |
| % |
70.7 ± 9.9 |
66.7 ± 8.6 |
<0.01 |
67.5 ± 6 |
82.0 ± 17.9 |
<0.05 |
76.3 ± 18.1 |
84.4 ± 16.8 |
<0.05 |
| WORK (Watt) |
108 ± 32 |
104 ± 30 |
Ns |
104 ± 18 |
114 ± 8 |
<0.05 |
115 ± 27 |
137 ± 33 |
<0.01 |
| AT (l/min) |
1.0 ± 0.3 |
1.0 ± 0.2 |
Ns |
0.9 ± 0.1 |
1.1 ± 0.1 |
<0.05 |
1.09 ± 0.3 |
1.05 ± 0.15 |
<0.05 |
| VE/VCO2 |
28.2 ± 2.4 |
27.8 ± 3.3 |
Ns |
22.4 ± 3.2 |
23.7 ± 1.9 |
Ns |
23.2 ± 2.3 |
22.2 ± 1.6 |
<0.05 |
| VO2/WORK | 9.5 ± 1.3 | 9.2 ± 0.8 | Ns | 9.7 ± 0.9 | 9.43 ± 3.3 | Ns | 9.3 ± 1.3 | 9.3 ± 0.8 | Ns |
Abbreviations: HOMA Homeostasis Model Assessment, BMI Body Mass Index, VO2peak Maximum oxygen uptake, % VO2 Maximum oxygen uptake in percentage compared to normal values, Work Maximum work, AT Anaerobic threshold, VE max Ventilation at maximum exercise, VCO2 carbon dioxide production, VO2/Work Oxygen uptake-Work rate relationship, VE/VCO2 Ventilatory equivalent for carbon dioxide.