TABLE 4 .
Lipid signature of M. tuberculosis grown in the fatty acid model
| Gene tag | Gene name | Functional categoryb | Function (reference) | RPKM ratioc |
P valued |
||
|---|---|---|---|---|---|---|---|
| FE/DE | FS/DS | FE vs DE | FS vs DS | ||||
| Rv0079a | 10 | Unknown; probable transduction regulatory protein (42) | 1.59 | 2.10 | 01.09 E-12 | 3.37 E-07 | |
| Rv0211 | pckA | 7 | Phosphoenolpyruvate carboxykinase | 1.03 | 1.83 | 0.021 | 4.03 E-14 |
| Rv0467 | icl-1 | 7 | Isocitrate lyase | 3.88 | 1.52 | 1.58 E-08 | 3.89 E-09 |
| Rv1066 | 10 | Unknown; rhodanase like domaine | 2.11 | 4.10 | 1.28 E-07 | 9.04 E-13 | |
| Rv1184c | 3 | Unknown; possible exported protein, probable lipase, esterase or quitinase (43) | 4.80 | 5.00 | 3.69 E-07 | 0.024 | |
| Rv1733ca | 3 | Unknown; probable conserved transmembrane protein | 2.77 | 1.50 | 2.62 E-08 | 0.012 | |
| Rv1996a | 0 | Unknown; universal stress protein family | 1.93 | 1.19 | 1.09 E-12 | 6.27 E-06 | |
| Rv2794c | pptT | 1 | 4′-Phosphopantetheinyl transferase | 1.18 | 3.00 | 0.041 | 8.33 E-05 |
| Rv3131a | 10 | Unknown; putative NAD(P)H nitroreductase | 2.89 | 4.00 | 1.09 E-12 | 9.04 E-13 | |
| Rv3134ca | 10 | Unknown; universal stress protein family | 1.03 | 3.43 | 5.99 E-06 | 3.19 E-10 | |
| Rv3416 | whiB3 | 9 | Redox sensor; transcriptional regulatory protein | 2.50 | 1.09 | 0.003 | 0.009 |
| Rv3612c | 10 | Unknown | 2.00 | 1.10 | 0.029 | 0.014 | |
| Rv3614c | espD | 3 | Unknown; ESX-1 secretion associated protein | 2.81 | 1.50 | 1.09 E-12 | 9.04 E-13 |
| Rv3686c | 10 | Unknown | 1.82 | 3.00 | 1.60 E-08 | 3.26 E-07 | |
Member of the DosR regulon.
Functional categories based on http://www.tuberculist.epfl.ch: 0, virulence, detoxification, and adaptation; 1, lipid metabolism; 3, cell wall and cell processes; 7, intermediary metabolism and respiration; 9, regulatory proteins; 10, conserved hypothetical proteins.
RPKM ratio according to phase of growth: exponential (FE/DE) or stationary (FS/DS). The gene is overexpressed in FE or FS if the ratio is >1. See Table S1A and B in the supplemental material for the complete set of data.
Determined by Fisher exact test, in which statistically significant differential expression between two conditions was determined by looking at genes with FDRs of <0.05 (see Materials and Methods for details).
http://genome.tbdb.org, accessed December 2012.