Fig. (3).

Vision for a future glioma treatment utilizing the potential of genetically enhanced microglia: two non-invasive strategies converging on the tumor. 1. Once the trafficking (entry into the CNS) and tracking (following glioma cells) behavior of the microglia can be controlled satisfactorily, these cells like other macrophages could also be employed to carry a payload [50, 51]. 2. Very precise and effective and therefore perhaps even curative tissue destruction/stimulation could then be achieved by means of a hadron beam [52]. 3. This approach may also allow real-time monitoring of the treatment if appropriate radiation sensors are implanted stereotactically (initially, for calibration purposes) and suitable radiochemicals for visualization become available. The glioma and its diffusely infiltrating cells is represented by the star. Coronal brain slice taken from inter BRAIN 1.1 for Windows, Springer 1998.