Table 2.
Biological Associations Relating to the IL4R Receptor
| Relation | Type | Reference |
|---|---|---|
| CD4 ---> IL4R | Regulation | [53, 54] |
| CD40 ---> IL4R | Expression | [55–58] |
| CD40LG --+> IL4R | Expression | [59, 60] |
| CD86 --+> IL4R | Regulation | [61] |
| IFNB1 ---> IL4R | Expression | [62] |
| IL12 --+> IL4R | Expression | [63–66] |
| IL13 --+> IL4R | Direct Regulation | [67–165] |
| IL1B ---> IL4R | Expression | [166–168] |
| IL4R --+> CD8A | Regulation | [169–171] |
| IL4R --+> CNR1 | Expression | [172] |
| IL4R --+> NGF | Molecular Transport | [173] |
| IL4R --+> STAT3 | Regulation | [174, 175] |
| IL4R ---- PTPN6 | Binding | [176–181] |
| IL4R ---- SOCS3 | Binding | [182] |
| IL4R ---- TP53 | Binding | [183] |
| IL4R ---> ADAM8 | Expression | [184] |
| IL4R ---> AKT1 | Regulation | [185, 186] |
| IL4R ---> CCL2 | Expression | [187] |
| IL4R ---> CD4 | Regulation | [188–195] |
| IL4R ---> CD86 | Expression | [57, 61, 196] |
| IL4R ---> EGFR | Regulation | [197] |
| IL4R ---> IL12 | Expression | [95, 198, 199] |
| IL4R ---> IL1B | Regulation | [83] |
| IL4R ---> MAPK14 | Regulation | [200] |
| IL4R ---> MAPK3 | Regulation | [156, 201] |
| IL4R ---> MAPK8 | Regulation | [156] |
| IL4R ---> STAT1 | Regulation | [202, 203] |
| IL4R ---| FAS | Regulation | [204, 205] |
| IL4R ---| IFNGR1 | Regulation | [202] |
| IL4R ---| MAPK1 | Regulation | [206] |
| IL4R ---| NOS2 | Regulation | [90] |
| IL4R ---| TLR4 | Regulation | [207] |
| MAPK1 --+> IL4R | Regulation | [208] |
| MAPK14 --+> IL4R | Expression | [209] |
| MIF --+> IL4R | Regulation | [210] |
| RAF1 ---> IL4R | Regulation | [211] |
| REL ---| IL4R | Expression | [212] |
| SOCS1 ---| IL4R | Regulation | [213] |
| STAT1 ---> IL4R | Expression | [214] |
| TNF --+> IL4R | Expression | [215–219] |
| TNFRSF1A ---> IL4R | Regulation | [217] |
--+>Positive influence.
---|Negative influence.
(Pathway Studio, Elsevier).