Figure 2.

TUDCA protects striatal mitochondria exposed to 3-NP in vivo. Top left: TUDCA rats exhibit normal striatal mitochondrial size and shape, with intact membrane structure. Bottom left: Enlarged view of TUDCA inset. Top center: Chronic (28 day) 3-NP administration results in abnormal mitochondria. Framed mitochondrion at the same magnification shows dramatic swelling, structural alterations, and loss of membrane integrity. Bottom center: Enlarged view of 3-NP inset. Top right: TUDCA protects mitochondria chronically exposed to 3-NP, as evidenced by normal mitochondrial size, shape, and structure. Bottom right: Enlarged view of 3-NP + TUDCA inset. Magnification is the same for all images. Scale bar, 1 μm.

Reprinted with permission from Keene et al, 2001.²⁷