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p38 MAPK signaling. (A) Phosphorylation of p38 in mouse cartilage in response to knee loading. (B) Phosphorylation of p38 in C28/I2 cells in response to fluid flow at 2 – 20 dyn/cm2. (C) Effects of SB203580 on phosphorylation of p38 in C28/I2 cells. (D) Effects of SB203580 on the mRNA levels of NGFβ and p75 in C28/I2 cells.
