Table 2.
Biological Studies on the Use of EPCs for Bone Healing
| Author | Species | Model | Target materials | Research purpose |
|---|---|---|---|---|
| Cetrulo et al.46 | nude rat | Systemic Transplantation to tibial distraction osteogenesis model | Human cultured EPCs | Mobilization and incorporation of EPCs |
| Laing et al.47 | Mouse | Femoral fracture model | EPCs (Sca1+cKit+MNCs) | Mobilization of EPCs |
| Laing et al.47 | Human | Tibial fracture | CD34+/CD133+ cells | Mobilization of CD34+/CD133+ cells |
| Matsumoto et al.31 | Mouse | Femoral fracture model | EPCs (KSL cells, Sca1+Lin- MNCs) | Mobilization and incorporation of EPCs |
| Lee et al.43 | Rat | Tibial distraction osteogenesis model | EPCs (DiI-Ac-LDL/FITC-lectin double-stained MNCs) | Mobilization of EPCs |
| Ma et al.48 | Human | Long bone traumatic fracture (Femur, Tibia, Fumerus) | CD34+/CD133+ cells | Mobilization of CD34+/CD133+ cells |
MNC, mononuclear cell.