Table 3.
Distribution of genotype frequencies in African American and Caucasian controls.
| Polymorphism | Genotype | African American | Caucasians | p |
|---|---|---|---|---|
| MTHFR 677C>T | CC | 67.9 (55) | 39.7 (25) | 0.0003 |
| CT | 29.6 (24) | 41.3 (26) | ||
| TT | 2.5 (2) | 19.0 (12) | ||
| MTHFR 1298A>C | AA | 69.1 (56) | 55.6 (35) | 0.0347 |
| AC | 30.9 (25) | 38.1 (24) | ||
| CC | 0 | 6.3 (4) | ||
| MTHFR 677/1298 | CC/AA | 46.9 (38) | 11.1 (7) | < 0.0001 |
| CC/AC | 21.0 (17) | 22.2 (14) | ||
| CC/CC | 0 | 6.3 (4) | ||
| CT/AA | 19.7 (16) | 25.4 (16) | ||
| CT/AC | 9.9 (8) | 15.9 (10) | ||
| TT/AA | 2.5 (2) | 19.0 (12) | ||
| CBS 844ins68 | WW | 58.0 (47) | 87.3 (55) | 0.0005 |
| WI | 39.5 (32) | 12.7 (8) | ||
| II | 2.5 (2) | 0 | ||
| MTR 2756A>G | AA | 58.0 (47) | 47.6 (30) | 0.19 |
| AG | 33.3 (27) | 47.6 (30) | ||
| GG | 8.7 (7) | 4.8 (3) | ||
| MTRR 66A>G | AA | 48.2 (39) | 20.6 (13) | 0.0009 |
| AG | 40.7 (33) | 50.8 (32) | ||
| GG | 11.1 (9) | 28.6 (18) | ||
| TYMS 1494del6 | Ins/ins | 19.7 (16) | 39.7 (25) | 0.0012 |
| Ins/del | 53.1 (43) | 54.0 (34) | ||
| Del/del | 27.2 (22) | 6.3 (4) | ||
| DHFR c.86+60_78 | Ins/ins | 19.7 (16) | 38.1 (24) | 0.0068 |
| Ins/del | 45.7 (37) | 47.6 (30) | ||
| Del/del | 34.6 (28) | 14.3 (9) |
Genotype frequencies % (n). P values by chi-square test.