Fig. 3.

Absence of donor class-I prevented the rejection of male islet grafts in sensitized female PD-1^−/− recipients. Top: Chemically induced diabetic female PD-1^−/− mice, previously sensitized with male spleen cells were transplanted with male class-I^−/− Rag^−/− (black solid line; n=5), class-II^−/− (black dashed line; n=3) or control Rag^−/− (Class-I & II^+/+) islet grafts (grey solid line; n=3). Bottom: Islets from male class-I^−/− Rag^−/− mice were transplanted to sensitized diabetic female B6 PD-1^−/− recipients (black dashed lines; n=5). Data shown are blood glucose levels of individual mice, and values for sensitized diabetic female B6 PD-1^−/− recipients of control female islets (black solid lines; n=5) are shown for comparison.