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. 2014 May 17;14:337. doi: 10.1186/1471-2407-14-337

Table 2.

Health-related Quality of Life in different levels of clinical characteristics

Clinical characteristics
 FACT-C c
SF-12 c
 
  PWB SWB EWB FWB CCS PF RP BP GH VT SF RE MH SF-6D c
Overall
 25.2 ± 3.8
 20.2 ± 4.2
 21.0 ± 3.1
 18.7 ± 4.0
 21.6 ± 3.4
 75.2 ± 29.9
 72.5 ± 27.8
 84.2 ± 25.2
 52.2 ± 26.6
 66.0 ± 17.9
 77.2 ± 30.4
 88.6 ± 19.9
 80.1 ± 14.7
 0.81 ± 0.13
AJCC Stage
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  Stage III (n = 115)
 25.5 ± 3.3
 20.0 ± 4.4
 21.1 ± 3.0
 19.0 ± 4.1
 21.3 ± 3.4
 75.7 ± 30.5
 74.2 ± 26.4
 83.8 ± 25.9
 52.4 ± 26.2
 65.7 ± 17.8
 78.8 ± 29.4
 89.6 ± 18.3
 80.1 ± 14.3
 0.82 ± 0.13
  Stage IV (n = 45)
 24.5 ± 4.6
 20.5 ± 3.8
 20.9 ± 3.3
 18.1 ± 3.9
 22.3 ± 3.3
 73.9 ± 28.7
 68.6 ± 30.9
 85.0 ± 23.5
 51.8 ± 27.8
 66.7 ± 18.5
 73.3 ± 32.6
 86.1 ± 23.3
 80.0 ± 15.9
 0.79 ± 0.14
  P-value
 0.142
 0.536
 0.720
 0.238
 0.123
 0.733
 0.264
 0.792
 0.899
 0.767
 0.313
 0.321
 0.964
 0.225
Primary Tumour Site
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  Colon (n = 90)
 25.5 ± 3.4
 20.5 ± 3.7
 21.2 ± 3.0
 18.6 ± 4.2
 22.2 ± 2.9
 77.6 ± 29.7
 73.7 ± 26.6
 84.6 ± 25.5
 53.5 ± 28.4
 67.2 ± 18.1
 79.1 ± 29.4
 87.8 ± 20.6
 82.3 ± 13.2
 0.81 ± 0.13
  Rectum (n = 70)
 24.9 ± 4.2
 19.7 ± 4.8
 20.7 ± 3.2
 18.8 ± 3.8
 20.9 ± 3.8
 71.9 ± 30.0
 70.9 ± 29.5
 83.6 ± 24.9
 50.5 ± 24.1
 64.5 ± 17.7
 74.6 ± 31.7
 89.6 ± 19.1
 77.1 ± 16.1
 0.81 ± 0.13
  P-value
 0.346
 0.214
 0.296
 0.809
 0.023a
 0.246
 0.545
 0.811
 0.493
 0.364
 0.375
 0.574
 0.035a
 0.873
Current Treatment
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  Yes (n = 51)
 25.9 ± 3.1
 20.1 ± 4.0
 21.0 ± 3.0
 19.1 ± 3.9
 21.8 ± 3.3
 78.3 ± 30.5
 76.4 ± 25.6
 84.5 ± 24.0
 55.6 ± 26.1
 68.0 ± 16.7
 82.0 ± 27.1
 89.3 ± 18.0
 80.0 ± 14.7
 0.83 ± 0.12
  No (n = 108)
 23.9 ± 4.6
 20.3 ± 4.7
 21.0 ± 3.1
 18.0 ± 4.3
 21.2 ± 3.5
 69.0 ± 27.9
 64.8 ± 30.6
 83.5 ± 27.5
 45.4 ± 26.5
 62.0 ± 19.7
 67.5 ± 34.3
 87.3 ± 23.3
 80.3 ± 15.0
 0.77 ± 0.14
  P-value
 0.003a
 0.797
 0.937
 0.113
 0.301
 0.074
 0.015a
 0.819
 0.026a
 0.053
 0.005a
 0.564
 0.922
 0.010a
Stoma
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  Yes (n = 21)
 24.8 ± 3.1
 20.2 ± 4.9
 20.7 ± 3.8
 17.2 ± 2.8
 20.7 ± 4.4
 71.3 ± 24.7
 60.6 ± 27.3
 75.0 ± 26.9
 49.3 ± 24.3
 61.3 ± 17.2
 61.3 ± 31.9
 89.4 ± 20.0
 76.9 ± 19.6
 0.77 ± 0.09
  No (n = 138)
 25.3 ± 3.9
 20.1 ± 4.1
 21.1 ± 3.0
 18.9 ± 4.2
 21.8 ± 3.2
 75.8 ± 30.6
 74.3 ± 27.5
 85.6 ± 24.7
 52.7 ± 27.0
 66.7 ± 18.0
 79.6 ± 29.5
 88.5 ± 20.0
 80.6 ± 13.8
 0.82 ± 0.14
  P-value
 0.545
 0.928
 0.580
 0.074
 0.185
 0.531
 0.040a
 0.080
 0.596
 0.204
 0.011a
 0.849
 0.296
 0.181
Vital Status
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  Alive (n = 145)
 25.3 ± 3.8
 20.4 ± 3.9
 21.0 ± 3.1
 18.9 ± 4.1
 21.6 ± 3.4
 77.4 ± 29.0
 74.4 ± 27.5
 84.6 ± 24.5
 54.0 ± 26.0
 65.8 ± 17.4
 78.3 ± 29.8
 88.6 ± 20.4
 79.7 ± 14.7
 0.82 ± 0.13
  Death (n = 15)
 24.5 ± 3.6
 18.1 ± 6.3
 20.8 ± 2.9
 17.2 ± 3.6
 21.9 ± 2.9
 53.6 ± 30.8
 53.6 ± 24.2
 80.4 ± 31.3
 35.0 ± 27.0
 67.9 ± 22.8
 66.1 ± 34.8
 88.4 ± 15.1
 83.9 ± 15.1
 0.73 ± 0.12
  P-value
 0.424
 0.064
 0.837
 0.137
 0.750
 0.004a
 0.007a
 0.554
 0.011a
 0.685
 0.152
 0.970
 0.306
 0.019a
CRC Recurrenceb
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  Yes (n = 22)
 24.3 ± 5.5
 20.9 ± 5.1
 20.2 ± 3.7
 18.8 ± 3.1
 22.0 ± 3.4
 67.0 ± 27.2
 57.4 ± 26.9
 79.5 ± 29.5
 51.8 ± 25.7
 65.9 ± 23.8
 68.2 ± 32.9
 91.5 ± 19.0
 83.5 ± 19.0
 0.77 ± 0.13
  No (n = 115)
 25.6 ± 3.4
 20.2 ± 4.0
 21.2 ± 2.9
 18.7 ± 4.4
 21.4 ± 3.5
 78.5 ± 29.2
 75.0 ± 27.2
 85.1 ± 24.6
 53.4 ± 26.2
 67.0 ± 16.7
 80.2 ± 29.4
 88.3 ± 20.0
 80.0 ± 14.2
 0.82 ± 0.13
  P-value 0.151 0.501 0.149 0.925 0.449 0.091 0.006a 0.350 0.791 0.801 0.090 0.499 0.315 0.073

Note: AJCC = American Joint Committee on Cancer.

FACT-C subscales: PWB = physical well-being; SWB = social well-being; EWB = emotional well-being; FWB = functional well-being; CCS = colorectal cancer subscale;

SF-12 subscales: PF = physical functioning; RP = role physical; BP = bodily pain; GH = general health; VT = vitality; SF = social functioning; RE = role emotional; MH = mental health.

aSignificant differences (P < 0.05) between groups by independent t-test.

bExcluded 23 subjects who had a prior CRC recurrence before the baseline assessment.

cHigher scores represent a higher level of functioning or a better HRQOL.