Table 3.
Crude and adjusted hazard ratio (95% CI) of risk factors for death by univariate and multivariate cox regression analysis
| |
Crude HR
a
|
Adjusted HR (FACT-C domain)
a
|
Adjusted HR (SF-12 domain)
a
|
Adjusted HR (SF-6D)
a
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Estimate | 95% CI | P-value | Estimate | 95% CI | P-value | Estimate | 95% CI | P-value | Estimate | 95% CI | P-value | |
| Primary Tumour Site (Colon) |
|
|
|
|
|
|
|
|
|
|
|
|
| Rectum |
1.213 |
(0.438,3.361) |
0.710 |
1.033 |
(0.233,4.589) |
0.966 |
0.561 |
(0.054,5.855) |
0.629 |
0.720 |
(0.212,2.454) |
0.600 |
| Active CRC Treatment (No) |
|
|
|
|
|
|
|
|
|
|
|
|
| Yes |
1.633 |
(0.569,4.682) |
0.362 |
1.039 |
(0.195,5.529) |
0.964 |
0.424 |
(0.052,3.432) |
0.421 |
1.007 |
(0.239,4.243) |
0.993 |
| Stoma (Present) |
|
|
|
|
|
|
|
|
|
|
|
|
| Absent |
0.812 |
(0.181,3.644) |
0.785 |
1.714 |
(0.212,13.840) |
0.613 |
0.046 |
(0.000,4.874) |
0.195 |
1.165 |
(0.189,7.168) |
0.869 |
| Time Since Diagnosis, months |
0.993 |
(0.974,1.011) |
0.427 |
0.998 |
(0.976,1.020) |
0.839 |
1.015 |
(0.992,1.040) |
0.199 |
1.003 |
(0.983,1.023) |
0.801 |
| AJCC (Stage III) |
|
|
|
|
|
|
|
|
|
|
|
|
| Stage IV |
1.898 |
(0.688,5.242) |
0.216 |
1.928 |
(0.365,10.193) |
0.440 |
2.791 |
(0.319,24.446) |
0.354 |
1.659 |
(0.371,7.411) |
0.508 |
| FACT-C |
|
|
|
|
|
|
|
|
|
|
|
|
| PWB |
0.966 |
(0.862,1.083) |
0.557 |
1.076 |
(0.857,1.352) |
0.527 |
|
|
|
|
|
|
| SWB |
0.908 |
(0.820,1.006) |
0.066 |
1.011 |
(0.870,1.174) |
0.889 |
|
|
|
|
|
|
| EWB |
0.965 |
(0.825,1.129) |
0.657 |
0.929 |
(0.683,1.264) |
0.639 |
|
|
|
|
|
|
| FWB |
0.905 |
(0.819,1.001) |
0.053 |
0.902 |
(0.722,1.128) |
0.365 |
|
|
|
|
|
|
| CCS |
1.008 |
(0.862,1.179) |
0.921 |
0.996 |
(0.796,1.247) |
0.972 |
|
|
|
|
|
|
| SF-12 |
|
|
|
|
|
|
|
|
|
|
|
|
| PF |
0.975 |
(0.960,0.991) |
0.003b |
|
|
|
0.917 |
(0.852,0.986) |
0.019b |
|
|
|
| RP |
0.975 |
(0.956,0.994) |
0.009b |
|
|
|
0.996 |
(0.944,1.051) |
0.882 |
|
|
|
| BP |
0.994 |
(0.976,1.013) |
0.552 |
|
|
|
1.055 |
(1.000,1.113) |
0.052 |
|
|
|
| GH |
0.970 |
(0.948,0.992) |
0.008b |
|
|
|
0.846 |
(0.746,0.958) |
0.009b |
|
|
|
| VT |
1.005 |
(0.976,1.034) |
0.754 |
|
|
|
1.151 |
(1.027,1.289) |
0.015b |
|
|
|
| SF |
0.987 |
(0.972,1.003) |
0.109 |
|
|
|
1.015 |
(0.970,1.063) |
0.523 |
|
|
|
| RE |
1.001 |
(0.975,1.027) |
0.944 |
|
|
|
0.983 |
(0.919,1.051) |
0.617 |
|
|
|
| MH |
1.016 |
(0.975,1.058) |
0.457 |
|
|
|
1.128 |
(1.005,1.265) |
0.040b |
|
|
|
| SF-6D |
0.007 |
(0.000,0.273) |
0.008b |
|
|
|
|
|
|
0.010 |
(0.000,0.573) |
0.026b |
| AIC |
|
|
|
128.2 |
111.2 |
131.4 |
||||||
| BIC |
|
|
|
187.3 |
179.8 |
179.1 |
||||||
| Harrell’s C-statistic | 0.824 (0.681,0.968) | 0.956 (0.909,1.002) | 0.799 (0.678,0.921) | |||||||||
Note: HR = Hazard ratio.
FACT-C subscales: PWB = physical well-being; SWB = social well-being; EWB = emotional well-being; FWB = functional well-being; CCS = colorectal cancer subscale;
SF-12 subscales: PF = physical functioning; RP = role physical; BP = bodily pain; GH = general health; VT = vitality; SF = social functioning; RE = role emotional; MH = mental health.
aHR > 1 indicates greater risk for death, with adjustment of socio-demographic characteristics.
bp-value < 0.05.