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Power results from phenotypic simulations based on 30 imputed VWF missense variants with MAF < 5%. A) 10% of missense variants within VWF have an effect on phenotype, with a fixed effect size. B) 10% of variants have an effect on phenotype, with effects sampled from a N(1,1/4) distribution. C) 20% of variants within VWF have an effect on phenotype, with a fixed effect size. D) 20% of variants within a gene have an effect on phenotype, with effects sampled from a N(1,1/4) distribution.
