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Xenografts are innervated. (A) Cross-section and (B) longitudinal section of 130-day xenografts demonstrate co-localization of presynaptic anti-SV2 reactivity (green) and postsynaptic α-bungarotoxin reactivity (red). Scale bars: 20 µm. (C) Immunohistochemistry demonstrates both type I (purple) and type II (green) myofibers in mature xenograft with a predominance of type I fibers. Asterisk indicates mouse muscle. Scale bar: 200 µm.
