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. 2014 Mar 26;5(5):340–345. doi: 10.1021/cn500019c

Figure 1.

Figure 1

PrP inhibits both spontaneous and seeded fibrillization of Aβ1–42. (○) Spontaneous (no seeds added) reaction for Aβ1–42 alone; (▽) Spontaneous reaction for Aβ1–42 in the presence of PrP; (●) Reaction for Aβ1–42 upon seeding with preformed Aβ1–42 fibrils; (▼) Reaction for Aβ1–42 upon seeding with preformed Aβ1–42 fibrils that were preincubated with PrP (Aβ:PrP molar ratio of 2:1). The final concentration of monomeric Aβ1–42, PrP, and Aβ1–42 seeds was 10, 0.5, and 1 μM, respectively. Fibrils used as seeds were presonicated to increase the number of ends.