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Urea dependence of the free energy change for forming the pseudoknot from the hairpin conformation for the wild-type human telomerase RNA pseudoknot (gray) and the dyskeratosis congenita mutant (orange) of the human telomerase RNA pseudoknot. Linear extrapolation to 0 M urea yields the 4.5(3) kcal/mol differential folding free energy between the WT and mutant pseudoknot under nondenaturing conditions.
