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Log-linear plot of the urea-dependent folding and unfolding kinetics for the (a) wild-type and (b) dyskeratosis congenita pseudoknots. For both constructs, the unfolding rate constant is substantially more sensitive to addition of urea than the folding rate constant, which suggests that most of the change in base solvent accessible surface area (SASA) occurs after formation of the transition state. Lines indicate trends and are not actual fits to the data.
