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. 2011 Aug 23;1(1):3–31. doi: 10.3390/biom1010003

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Predicted domains and transmembrane helix for human ITB2 and ITB4. Domains and key regions are identified for ITB2 and ITB4 amino acid sequences using NCBI web tools (http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi) to identify functional domains and ExPasy web tools to identify predicted transmembrane domains (TMHMM) (http://www.cbs.dtu.dk/services/TMHMM-2.0/); INB or integrin_beta; integrin B tail (in pink); TMHMM transmembranes (in red); cytosolic domain (in blue); Calx-beta domain (in green); FN3 (fibronectin 3), cytokine receptor and interdomain contacts (red triangles); Note: lack of FN3 binding domains and the cytokine receptor motifs in β4 subunit that interacts only with laminin-332.