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. 2011 Aug 23;1(1):3–31. doi: 10.3390/biom1010003

Figure 3.

Figure 3

Amino acid sequence alignments for vertebrate ITB cytosolic domain sequences. (A) Comparison and alignments of human ITB1 major isoforms for cytosolic domain sequences; (B) Consensus sequences of vertebrate ITB cytosolic domains; see Table 1 for sources of beta integrin cytosolic domain sequences: * shows identical residues for ITB subunits; : similar alternate residues;. dissimilar alternate residues; α-helix for vertebrate ITB sequences is in shaded yellow; β-sheet is in shaded grey; colors for amino acids are shown as: basic (R and K); acidic (D and E); neutral hydrophilic (G, Y, Q, S, T, N, Y, C, H); and hydrophobic (M, A, F, I, L, W, P, V); the Cyto-1, Cyto-2 (NPXY) and Cyto-3 (NXXY) domains are shown in dotted lines (see text for details).