Skip to main content
. 2012 May 24;2(2):269–281. doi: 10.3390/biom2020269

Figure 4.

Figure 4

SENP1 is required for NADPH-dependent amplification of exocytosis. (A) Mouse β-cells were maintained at a non-stimulatory glucose concentration (1 mM) for 2 hours prior to intracellular dialysis of NADPH/NADP+ at a molar ratio 10:1 and whole-cell patch-clamp measurement of exocytosis; (B,C) Representative traces (B) of exocytotic responses and averaged data (C) in control cells (Ad-sh-scramble) or following SENP1 knockdown (Ad-sh-SENP1). ** p < 0.01 and *** p < 0.001 compared with Ad-sh-scramble.