Table 3.

Summary of Studies on SNPs Associated with MiRNA or Target Gene Expression.

Study	Samples	Expression data	Genotype data	Candidate SNPs
Huang et al. [45]	LCLs from 53 CEU and 54 YRI HAPMAP subjects	miRNA microarray data	HapMap release 24	272 SNPs with high population differentiation significantly associated with 33 differentially expressed miRNAs
Gamazon et al. [46]				31 genome-wide significant SNPs associated with miRNA expression
	LCLs from 87 CEU and 89 YRI HAPMAP subjects	mRNA microarray data		25 SNPs in CEU and 25 in YRI potentially affect miRNA binding and mRNA expression
Richardson et al. [12]	160 fat cell biopsy, 166 LCLs and 160 skin punch biopsy from healthy twins in MuTHER study [49]	mRNA microarray data	Genotype data from MuTHER study	Four SNPs associated with expression and disease phenotypes potentially via altering miRNA target sites
Zhang et al. [28]	LCLs from 87 CEU and 89 YRI HAPMAP subjects	mRNA microarray data	HapMap release 27	17 SNPs in CEU and 9 in YRI potentially affect mRNA expression via altering miRNA binding sites
Lu et al. [44]	LCLs from 32 CEU, 41 CHB, 39 JPT and 37 YRI HAPMAP subjects	mRNA microarray data	1000 Genomes Project Phase 1	14 genetic variants significantly associated with mRNA expression via direct or indirect targeting