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. 2013 Feb 28;3(1):226–241. doi: 10.3390/biom3010226

Figure 1.

Figure 1

Schematic diagram of long noncoding RNA discovery and function analysis using genome-wide methods. (a) Genomic locations for long noncoding RNA (lncRNA) transcription. Boxes shown as annotated genes and exons. Arrows label the direction of transcription. (b) Methodology for lncRNA discovery and functional association with proteins. H3K4me3 signature defines transcription initiation. H3K36me3 signature defines transcription elongation. Signals of poly(A)+RNA-seq indicate polyadenylated RNAs (including most annotated mRNAs and lncRNAs). Signals of poly(A)-RNA-seq indicate non-polyadenylated RNAs, including recently identified intronic transcripts. Signals of CLIP-seq/RIP-seq reveal the association of RNA transcripts with RNA binding proteins.