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. 2012 Dec 21;3(1):1–17. doi: 10.3390/biom3010001

Figure 2.

Figure 2

Domain structure of different PARG proteins. The full-length human PARG111 contains an N-terminal regulatory region (A-domain; blue) which includes a nuclear localisation signal (NLS), PCNA binding motif (PIP box) and a nuclear export signal (NES). Full length human PARG also contains a mitochondrial targeting sequence (MTS), a highly structured and conserved B-domain (red), and the essential catalytic macrodomain (C-domain; green). Two shorter isoforms of human PARG, PARG102 and PARG99, lack the NLS and PIP box, while PARG60 lacks the entire regulatory region. Human and Tetrahymena thermophila PARGs represent canonical-type PARGs and share high conservation in their B-domain and macrodomain. Highly divergent bacterial-type PARG represented by Thermomonospora curvata PARG contains the catalytic macrodomain and an N-terminal accessory element (yellow).