Table 1.
Test Method | Measured Property | ASTM Standards | Measured CNS data | Refs. |
---|---|---|---|---|
Magnetic Resonance Elastography | Shear Modulus | N/A | HUMAN: Grey 5.22 kPa; | [191] |
White 13.6 kPa @ 100 Hz | ||||
Shear Storage/ Loss Modulus | HUMAN: G' (Storage) = 1.13 kPa; | [192] | ||
G" (Loss) = 0.935 kPa @100 Hz | ||||
Shear Modulus | HUMAN: 3.5 kPa @ 83.33 Hz | [193,194] | ||
G'(Storage) Grey matter = 3.1 kPa | ||||
G'(Storage) White matter = 2.7 kPa @200 Hz | ||||
Dynamic Testing | Shear Storage/ Loss Modulus | D4065 | PRIMATE: G' = 0.6-1.1 kPa; | [194] |
G" = 0.35-0.6 kPa @ 9-10 Hz | ||||
Dynamic Elastic Modulus | HUMAN : E' = 67 kPa; E" = 26 kPa; | [195] | ||
E*=72 kPa @ 34 Hz | ||||
PRIMATE : E' = 91 kPa; E" = 54 kPa; | ||||
E* = 105 kPa @ 31 Hz | ||||
Dynamic Storage/ Loss Modulus | HUMAN: Storage: 0.39 kPa, 0.47 kPa, 0.65 kPa | [196] | ||
Loss: 0.075 kPa, 0.094 kPa, 0.190 kPa @ 0.1, | ||||
1 and 10 Hz respectively | ||||
Compression Testing | Elastic Modulus | D1621, D695, D575 | PORCINE 5.7 kPa @ 1 s−1; | [197] |
11.9 kPa @ 10 s−1; 23.8 kPa @ 50 s−1 | ||||
Shear ModulusMooney Rivlin Material Model | BOVINE : 2.26 kPa | [198] | ||
(Equation constants for Mooney-Rivlin Model) | ||||
Elastic Modulus | PORCINE: 38.5 kPa | [199] | ||
Tensile Testing | Elastic Modulus | D1708 | PORCINE: 4.2 kPa @ .9 s−1; | [197] |
4.0 kPa @ 4.3 s−1; 18.6 kPa @ 25 s−1 | ||||
Pressure/Volume Testing | Elastic Modulus | N/A | PRIMATE (in vivo): 10.0-3.50 kpa | [200] |
Relaxation Testing | Relaxation Modulus | D6048 | HUMAN: 6.6 kPa @ 34 Hz | [196] |
PRIMATE: 10.3 kPa @ 31 Hz | ||||
Indentation Testing | Shear Modulus | E2546 | PORCINE: Grey Matter 0.74 kPa; | [201]* |
White Matter 1.03 kPa @ 0.1 mm/s | ||||
Elastic/Shear Modulus | RAT: 13-17 day old: 3.34 kPa; | [202]* | ||
43-90 day old: 1.72 kPa | ||||
Shear modulus and Relaxtion functions | PORCINE: Short Term: In vivo 1.88 kPa; | [203] | ||
In Situ 2.80 kPa; In Vitro 1.36 kPa | ||||
Long Term: In vivo 0.685 kPa; | ||||
In Situ 0.926 kPa; In Vitro 0.468 kPa | ||||
Atomic Force Microscopy | Elastic/Shear Modulus | E42, | RAT (hippocampus): pyramidal layer: | [204] |
CA1 0.14 kPa; CA3 0.23 kPa | ||||
E2382 | stratum radiatum: CA1 0.17 kPa; | |||
CA3 0.31 kPa @ 3µm indentation |
* It should be noted that these authors calculated Shear Modulus from indentation data per a formula derived by Lee and Radok in 1960. This value is normally calculated using dynamic or oscillatory methods. ASTM standard provides guidelines for using indentation to calculate Elastic modulus.