Table 3.
Material characteristics and scenarios of normal tissue exposure.
| Material Characteristic | Loading Description | Possible Implications | Load Scenario |
|---|---|---|---|
| Creep/Relaxation Behavior | Constant Pressure | Permanent deformation | Static pressure on brain tissue from surrounding tissue, fluid, and bone |
| Change in elastic modulus | |||
| Fatigue Stress Behavior | Cyclic pressure | Permanent deformation | Normal intracranial pressure fluctuationsGlial cell migration through microenvironments |
| Changes in material properties | |||
| (i.e., white matter tracts/ spinal cord) | |||
| Hardening/crystallization | |||
| Fracture/Failure | |||
| Fatigue Strain Behavior | Cyclic deformation | Permanent deformation | Normal intracranial pressure fluctuations |
| Changes in material properties | |||
| Hardening/crystallization | Motion in spinal cord within the vertebrae | ||
| Fracture/Failure | |||
| Stress/Strain Recovery | Tension or Compression | Permanent deformation | Flexion or extension in spinal cord within vertebrae |
| Intracranial hyper/hypotension | |||
| Normal intracranial pressure fluctuations |